{"id":9140,"date":"2020-06-09T17:26:38","date_gmt":"2020-06-09T15:26:38","guid":{"rendered":"https:\/\/staging.ggba.swiss\/des-organoides-pour-la-medecine-personnalisee\/"},"modified":"2023-07-04T13:43:23","modified_gmt":"2023-07-04T11:43:23","slug":"des-organoides-pour-la-medecine-personnalisee","status":"publish","type":"post","link":"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/","title":{"rendered":"Des organo\u00efdes pour la m\u00e9decine personnalis\u00e9e"},"content":{"rendered":"

Une avanc\u00e9e r\u00e9cente du Laboratoire de bio-ing\u00e9nierie des cellules souches de l\u2019EPFL permettra pour la premi\u00e8re fois la production en s\u00e9rie d\u2019organo\u00efdes standardis\u00e9s. Cette technologie va ouvrir la voie \u00e0 une utilisation plus large des organo\u00efdes pour le d\u00e9veloppement de nouveaux m\u00e9dicaments et le diagnostic personnalis\u00e9.<\/h4>\n

Les organo\u00efdes sont de minuscules cultures de tissus tridimensionnelles d\u00e9riv\u00e9es de cellules souches. Ils sont con\u00e7us pour imiter la fonctionnalit\u00e9 des organes et jouent un r\u00f4le essentiel dans le d\u00e9veloppement de la m\u00e9decine personnalis\u00e9e et le test de nouveaux m\u00e9dicaments. Toutefois, l\u2019utilisation des organo\u00efdes \u00e0 large \u00e9chelle se heurte \u00e0 leur croissance d\u00e9sordonn\u00e9e.<\/p>\n

Le Laboratoire de bio-ing\u00e9nierie des cellules souches<\/a> de l\u2019EPFL<\/a> a mis au point des pastilles de gel microstructur\u00e9es<\/a> qui permettent aux cellules de s\u2019organiser. Ces pastilles sont perc\u00e9es d\u2019une multitude d\u2019orifices de quelques microm\u00e8tres de diam\u00e8tre dont le fond est en forme de U. Les cellules instill\u00e9es \u2013 une centaine par trou \u2013 s\u2019y regroupent et forment une colonie relativement compacte en une trentaine de minutes. Ainsi emprisonn\u00e9es, elles se d\u00e9veloppent et se diff\u00e9rencient pour donner, environ 60 heures plus tard, des organo\u00efdes fonctionnels.<\/p>\n

La nouvelle technologie a \u00e9t\u00e9 utilis\u00e9e avec succ\u00e8s dans une \u00e9tude men\u00e9e au Centre hospitalier universitaire de Lausanne (CHUV<\/a>) pour tester des mol\u00e9cules m\u00e9dicamenteuses sur un cancer colorectal. Le diam\u00e8tre, la profondeur et l\u2019espacement entre les microcavit\u00e9s peuvent varier, ainsi que la composition du gel, ce qui permet de faire pousser des tissus de diff\u00e9rents types et de taille variable.<\/p>\n

Deux des chercheuses \u00e0 l\u2019origine de cette avanc\u00e9e, Nathalie Brandenberg et Sylke Hoehnel, ont lanc\u00e9 une start-up, SUN bioscience<\/a>, pour commercialiser cette technologie.<\/p>\n","protected":false},"excerpt":{"rendered":"

Une avanc\u00e9e r\u00e9cente du Laboratoire de bio-ing\u00e9nierie des cellules souches de l\u2019EPFL permettra pour la premi\u00e8re fois la production en s\u00e9rie d\u2019organo\u00efdes standardis\u00e9s. Cette technologie va ouvrir la voie \u00e0 une utilisation plus large des organo\u00efdes pour le d\u00e9veloppement de nouveaux m\u00e9dicaments et le diagnostic personnalis\u00e9. Les organo\u00efdes sont de minuscules cultures de tissus tridimensionnelles […]<\/p>\n","protected":false},"author":3,"featured_media":9141,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"mc4wp_mailchimp_campaign":[]},"categories":[843,842],"tags":[1068],"acf":[],"yoast_head":"\nDes organo\u00efdes pour la m\u00e9decine personnalis\u00e9e - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Des organo\u00efdes pour la m\u00e9decine personnalis\u00e9e - Greater Geneva Bern area\" \/>\n<meta property=\"og:description\" content=\"Une avanc\u00e9e r\u00e9cente du Laboratoire de bio-ing\u00e9nierie des cellules souches de l\u2019EPFL permettra pour la premi\u00e8re fois la production en s\u00e9rie d\u2019organo\u00efdes standardis\u00e9s. Cette technologie va ouvrir la voie \u00e0 une utilisation plus large des organo\u00efdes pour le d\u00e9veloppement de nouveaux m\u00e9dicaments et le diagnostic personnalis\u00e9. Les organo\u00efdes sont de minuscules cultures de tissus tridimensionnelles […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/\" \/>\n<meta property=\"og:site_name\" content=\"Greater Geneva Bern area\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-09T15:26:38+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-07-04T11:43:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/Sun-bioscience-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"945\" \/>\n\t<meta property=\"og:image:height\" content=\"430\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"mathieu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"mathieu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/\",\"url\":\"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/\",\"name\":\"Des organo\u00efdes pour la m\u00e9decine personnalis\u00e9e - Greater Geneva Bern area\",\"isPartOf\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#website\"},\"datePublished\":\"2020-06-09T15:26:38+00:00\",\"dateModified\":\"2023-07-04T11:43:23+00:00\",\"author\":{\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/8e5f085a3c4b5b152358afca41905511\"},\"breadcrumb\":{\"@id\":\"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/staging.ggba.swiss\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Des organo\u00efdes pour la m\u00e9decine personnalis\u00e9e\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#website\",\"url\":\"https:\/\/staging.ggba.swiss\/en\/\",\"name\":\"Greater Geneva Bern area\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/staging.ggba.swiss\/en\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/8e5f085a3c4b5b152358afca41905511\",\"name\":\"mathieu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/066e0c4bb04d41ae36e3347b25b925cc?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/066e0c4bb04d41ae36e3347b25b925cc?s=96&d=mm&r=g\",\"caption\":\"mathieu\"},\"url\":\"https:\/\/staging.ggba.swiss\/fr\/author\/mathieu\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Des organo\u00efdes pour la m\u00e9decine personnalis\u00e9e - Greater Geneva Bern area","robots":{"index":"noindex","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"og_locale":"fr_FR","og_type":"article","og_title":"Des organo\u00efdes pour la m\u00e9decine personnalis\u00e9e - Greater Geneva Bern area","og_description":"Une avanc\u00e9e r\u00e9cente du Laboratoire de bio-ing\u00e9nierie des cellules souches de l\u2019EPFL permettra pour la premi\u00e8re fois la production en s\u00e9rie d\u2019organo\u00efdes standardis\u00e9s. Cette technologie va ouvrir la voie \u00e0 une utilisation plus large des organo\u00efdes pour le d\u00e9veloppement de nouveaux m\u00e9dicaments et le diagnostic personnalis\u00e9. Les organo\u00efdes sont de minuscules cultures de tissus tridimensionnelles […]","og_url":"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/","og_site_name":"Greater Geneva Bern area","article_published_time":"2020-06-09T15:26:38+00:00","article_modified_time":"2023-07-04T11:43:23+00:00","og_image":[{"width":945,"height":430,"url":"https:\/\/staging.ggba.swiss\/app\/uploads\/2023\/06\/Sun-bioscience-2.jpg","type":"image\/jpeg"}],"author":"mathieu","twitter_card":"summary_large_image","twitter_misc":{"Written by":"mathieu","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/","url":"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/","name":"Des organo\u00efdes pour la m\u00e9decine personnalis\u00e9e - Greater Geneva Bern area","isPartOf":{"@id":"https:\/\/staging.ggba.swiss\/en\/#website"},"datePublished":"2020-06-09T15:26:38+00:00","dateModified":"2023-07-04T11:43:23+00:00","author":{"@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/8e5f085a3c4b5b152358afca41905511"},"breadcrumb":{"@id":"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/staging.ggba.swiss\/fr\/des-organoides-pour-la-medecine-personnalisee\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/staging.ggba.swiss\/en\/"},{"@type":"ListItem","position":2,"name":"Des organo\u00efdes pour la m\u00e9decine personnalis\u00e9e"}]},{"@type":"WebSite","@id":"https:\/\/staging.ggba.swiss\/en\/#website","url":"https:\/\/staging.ggba.swiss\/en\/","name":"Greater Geneva Bern area","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/staging.ggba.swiss\/en\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fr-FR"},{"@type":"Person","@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/8e5f085a3c4b5b152358afca41905511","name":"mathieu","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/staging.ggba.swiss\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/066e0c4bb04d41ae36e3347b25b925cc?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/066e0c4bb04d41ae36e3347b25b925cc?s=96&d=mm&r=g","caption":"mathieu"},"url":"https:\/\/staging.ggba.swiss\/fr\/author\/mathieu\/"}]}},"_links":{"self":[{"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/9140"}],"collection":[{"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/comments?post=9140"}],"version-history":[{"count":1,"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/9140\/revisions"}],"predecessor-version":[{"id":17776,"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/posts\/9140\/revisions\/17776"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/media\/9141"}],"wp:attachment":[{"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/media?parent=9140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/categories?post=9140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.ggba.swiss\/fr\/wp-json\/wp\/v2\/tags?post=9140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}