{"id":7995,"date":"2016-06-22T11:33:00","date_gmt":"2016-06-22T09:33:00","guid":{"rendered":"https:\/\/staging.ggba.swiss\/cancer-du-sein-nouvelles-therapies-en-vue\/"},"modified":"2023-07-04T13:42:59","modified_gmt":"2023-07-04T11:42:59","slug":"cancer-du-sein-nouvelles-therapies-en-vue","status":"publish","type":"post","link":"https:\/\/staging.ggba.swiss\/fr\/cancer-du-sein-nouvelles-therapies-en-vue\/","title":{"rendered":"Cancer du sein : nouvelles th\u00e9rapies en vue"},"content":{"rendered":"<p><b>Dans une nouvelle \u00e9tude, des chercheurs de l\u2019Universit\u00e9 de Gen\u00e8ve d\u00e9voilent un m\u00e9canisme de r\u00e9sistance au Tamoxif\u00e8ne, un traitement anti-\u0153strog\u00e8nes.<\/b><\/p>\n<p>Les \u0153strog\u00e8nes sont responsables de la survie et de la prolif\u00e9ration des cellules tumorales chez 70% des femmes qui souffrent d\u2019un cancer du sein. Le Tamoxif\u00e8ne, un anti-\u0153strog\u00e8nes, constitue le traitement phare contre ce type de cancer. Au fil du temps, pr\u00e8s d\u2019un tiers des patientes d\u00e9veloppent toutefois une r\u00e9sistance \u00e0 ce type de th\u00e9rapie. Des biologistes de l\u2019Universit\u00e9 de Gen\u00e8ve (<link http:>UNIGE<\/link>) ont d\u00e9couvert comment cette r\u00e9sistance se met en place, en identifiant huit facteurs impliqu\u00e9s dans ce m\u00e9canisme. Leur \u00e9tude, qui pourrait ouvrir la voie \u00e0 de nouvelles pistes th\u00e9rapeutiques, a \u00e9t\u00e9 publi\u00e9e dans la revue <link http:>Nucleic Acids Research<\/link>.<\/p>\n<p>Didier Picard, professeur au D\u00e9partement de biologie cellulaire de la Facult\u00e9 des sciences de l\u2019UNIGE, et son \u00e9quipe, ont d\u00e9couvert que plusieurs enzymes entrent en jeu pour permettre aux r\u00e9cepteurs aux \u0153strog\u00e8nes de type \u03b1, qui constituent un moteur de croissance canc\u00e9reuse, d\u2019acc\u00e9der aux g\u00e8nes n\u00e9cessaires \u00e0 la croissance de la cellule. Divers complexes prot\u00e9iques et cofacteurs sont \u00e9galement impliqu\u00e9s dans le processus. La d\u00e9couverte d\u2019un \u00e9ventail de facteurs aux fonctions inattendues a incit\u00e9 les scientifiques \u00e0 les tester comme cibles th\u00e9rapeutiques potentielles, explique un <link http:>communiqu\u00e9 de presse<\/link> de l\u2019universit\u00e9. Les biologistes ont test\u00e9 in vitro diff\u00e9rents compos\u00e9s chimiques sur des cellules tumorales devenues r\u00e9fractaires au Tamoxif\u00e8ne. Ils ont d\u00e9couvert que les substances qui inhibent les facteurs d\u00e9couverts au cours de l\u2019\u00e9tude freinent \u00e9galement la multiplication des cellules canc\u00e9reuses. De plus, elles rendent les cellules malignes \u00e0 nouveau sensibles au Tamoxif\u00e8ne.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dans une nouvelle \u00e9tude, des chercheurs de l\u2019Universit\u00e9 de Gen\u00e8ve d\u00e9voilent un m\u00e9canisme de r\u00e9sistance au Tamoxif\u00e8ne, un traitement anti-\u0153strog\u00e8nes. Les \u0153strog\u00e8nes sont responsables de la survie et de la prolif\u00e9ration des cellules tumorales chez 70% des femmes qui souffrent d\u2019un cancer du sein. Le Tamoxif\u00e8ne, un anti-\u0153strog\u00e8nes, constitue le traitement phare contre ce type [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"mc4wp_mailchimp_campaign":[]},"categories":[842],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.10 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cancer du sein : nouvelles th\u00e9rapies en vue - Greater Geneva Bern area<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cancer du sein : nouvelles th\u00e9rapies en vue - Greater Geneva Bern area\" \/>\n<meta property=\"og:description\" content=\"Dans une nouvelle \u00e9tude, des chercheurs de l\u2019Universit\u00e9 de Gen\u00e8ve d\u00e9voilent un m\u00e9canisme de r\u00e9sistance au Tamoxif\u00e8ne, un traitement anti-\u0153strog\u00e8nes. 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